Bournemouth shocked champions Manchester City, who hadn't lost in the Premier League since December. Newcastle rocked Arsenal, and Liverpool took the top position on Saturday.
After losing to Aston Villa last season, City went on a 32-game winning streak in the league.
However, Pep Guardiola's second-placed team abruptly ended that run with a 2-1 defeat on the south coast of England.
The Cherries had lost 19 of their 21 previous encounters against City, but Andoni Iraola's squad pulled off a stunning shock to prevent the champions from defending their championship.
Just recently, Bournemouth beat City 2-0 at the Vitality Stadium, which hurt Arsenal's championship aspirations.
City's fitness issues in Wednesday's League Cup loss at Tottenham led Guardiola to declare an injury "emergency" for his team.
City were stunned in the ninth minute—exhausted or not—as Antoine Semenyo, a winger for Bournemouth, hammered a cross from Milos Kerkez past Ederson from inside the box.
In the 64th minute, Bournemouth increased their advantage thanks to a controlled finish from Kerkez's cross, and Guardiola's players failed to respond to that blow.
City suffered their second loss in as many days despite a late heroic effort by Josko Gvardiol, whose header in the 82nd minute trimmed the lead.
Because of this imbalance, several guys aren't getting any playing time. We were overwhelmed by their ferocity today, and according to Guardiola, it was the reason for our defeat.
Newcastle severely damaged fourth-placed Arsenal's championship hopes with their 1-0 victory at St. James' Park.
The goal came in the 12th minute from a precise cross by Anthony Gordon, which Alexander Isak headed home.
Those impacted by injuries Throughout the game, Arsenal failed to score a single shot because they could not move out of first gear.
Mikel Arteta's squad has dropped all three points in their last three games after finishing second to City the previous two seasons.
"We failed to live up to our potential today. What matters is your response to it. Despite being seven points behind first place, Arteta's team struggles to find the perfect words to express their emotions.
Liverpool's late power surge
At Anfield, Liverpool was on the verge of a shocking defeat before refocusing and capitalizing on Brighton's mistakes to secure a 2-1 victory.
Brighton took the lead in the fourteenth minute with a ferocious effort from Ferdi Kadioglu. Danny Welbeck had flicked on a cross from Kaoru Mitoma, and the ball cannoned in off the post.
Midweek, Liverpool had overcome Brighton in the League Cup last 16, and this time around, they pulled off the same feat with a late comeback.
Cody Gakpo scored the equalizer in the 69th minute, whose cross floated directly into the goal.
After just three minutes, Mohamed Salah gave Liverpool the lead. The Egyptian striker scored his ninth season goal with a beautiful curling finish into the top corner.
After ten league games under Arne Slot's leadership, Liverpool had won eight, putting them two points ahead of Manchester City.
"More than the position we are in, if you face a team like this and are 1-0 down and can come back to a 2-1 win, that gives me a lot of confidence," Slot said.
After a 3-0 win against 10-man West Ham, Nottingham Forest moved up to third position in the league. This was their best three-game winning streak since 1999.
During first-half stoppage time, West Ham had Edson Alvarez sent off, and in the 27th minute, Chris Wood scored his eighth goal in ten league appearances.
Callum Hudson-Odoi scored in the 65th minute at the City Ground, and Ola Aina put the game away 12 minutes before the end of the match.
At Portman Road, third-bottom Ipswich were denied their first Premier League victory since 2002 when Jordan Ayew scored the equalizer in stoppage time, resulting in a 1-1 draw for Leicester.
Although Ipswich took the lead on a shot by Leif Davis in the 55th minute, the hosts saw Kalvin Phillips sent off in the 77th minute.
Towards the back, Adam Armstrong scored the game-winning goal for Southampton in the 85th minute, giving them their first league victory of the season, a 1-0 victory against Everton.
Crystal Palace drew a 2-2 draw at Molineux thanks to an equalizer by Marc Guehi in the 77th minute, keeping winless Wolves in last place in the league.
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